I've looked at almost all the websites talking about GRX and watched a good amount of Youtube videos about the GRX line, but other than about 60 grams, are there any other differences between the mechanical versions or the 600 and 800 series??
Shimano GRX 800 and 600 series are both 11 speed. GRX 400 is 10spd. The difference between 800 and 600 is the 800/810 has Servo wave for increased power when braking.
I think it's only on the mech version not the Di2 as far as I see. I don't know. I have the 600 levers and I don't ever feel like there's a loss of power. My Enduro bike is quite a bit heavier with Servo wave and I guess it helps there but it's 34lbs vs 20 for my gravel bike.
Not strictly for OP, but here's all the 11spd stuff... Di2 Lever: - higher pivot - servo-wave - free stroke adjust - very different hood shape and texture - secondary button placement on the inside top of the shifter (compared to ST-8070) 810 Lever: - servo wave - free stroke adjust - different hood texture only - is pretty much rebranded Ultegra with a scalloped lever blade and a different hood texture 600 Lever: - is pretty much rebranded 105 with a scalloped lever blade